The FDA had a meeting the last two days: FDA is convening this two-day meeting to seek the Panel’s expert opinion and input on scientific issues concerning Direct to Consumer (DTC) genetic tests that make medical claims. This meeting is focused specifically on issues regarding clinical genetic tests that are marketed directly to consumers (DTC… Continue reading Your Genes, Regulated?
Category: Science and Technology
Eurogenes
Davidski of Eurogenes is also a genome blogger. In his admixture analysis for West, South and Central Asians, I am PKEG1 and my results are as follows: European 4% Siberian 1% Caucasus 32% Sub-Saharan African 4% Middle Eastern 9% East Asian 1% South Asian 50% Here’s a chart showing some of the reference samples and… Continue reading Eurogenes
Dodecad Project II
I talked about the Dodecad Project last time. Dienekes also did some cluster analysis using mclust. When he classified everybody into 48 clusters, I showed up almost all alone in cluster 21. Only one other member who is a Bihari Brahmin had a 50% chance of belonging in my cluster. With 56 clusters, I am… Continue reading Dodecad Project II
Dodecad Ancestry Project
I asked Dienekes to include me in his Dodecad Ancestry Project and he gave me the following results: Ancestral Component Percentage South Asian 44.9% West Asian 33.7% Southwest Asian 5.7% North European 5.5% South European 3.7% East African 3.4% Northwest African 2.1% West African 0.6% East Asian 0.4% Northeast Asian 0.1% You can see the… Continue reading Dodecad Ancestry Project
McDonald Ancestry Analysis II
When my sister got her 23andme results, we sent them over to Doug McDonald. I was expecting something close to my results, but it was radically different: This one is different it says 37% Druze, 4% Bushman or Pygmy, the rest North India. It is complicated enough that the program refuses to generate a spot… Continue reading McDonald Ancestry Analysis II
Doug McDonald Ancestry Analysis
As I noted last time, I was in a situation where I needed some help into ascertaining my genetic ancestry. Fortunately, there are people willing to do that sort of analysis for you. One of these is Doug McDonald. So I sent him my data and within an hour I had an analysis. The PCA… Continue reading Doug McDonald Ancestry Analysis
Genome Similarity
23andme has a feature where you can find out how similar your genes are to your friends and family (who you are sharing with at the site). The result is a bar list with percentages showing similarity. The number next to each person in the bar list is a measure of similarity. Specifically, it is… Continue reading Genome Similarity
My Biogeographical Ancestry
There are several different ways to figure out your genetic ancestry. One way that 23andme shows your ancestry is by comparison with reference populations of the HGDP (Human Genome Diversity Project) dataset. I have listed how similar I am to various groups in the table below: Reference Population Similarity Groups Included Central & South Asians… Continue reading My Biogeographical Ancestry
Ancestry Painting
23andme has a feature called ancestry painting which gives you the percentages of different populations you are admixed from. In my case, I got the following: European 91.22% Asian 8.69% African 0.09% Ignore the precision (to 2 decimal places). I showed that because I wanted to highlight the nonzero African ancestry percentage which I will… Continue reading Ancestry Painting
Harappa Ancestry Project Update
I have got 25 participants to the Harappa Ancestry Project now. But we still need more especially from the Hindi belt. I have been detailing the datasets I am using: HapMap Human Genome Diversity Project (HGDP) Singapore Genome Variation Project Behar et al Data Xing et al Data Reference Dataset I Reference Dataset II I… Continue reading Harappa Ancestry Project Update